AIIMS MAY 2010: Post-Graduate Medical Entrance Examination MCQS ANAESTHESIA 1. The volatility of an anesthetic agent is directly proportional to lowering the flow in the portal vein. Portal flow is maximally reduced by â€“ A. ether B. halothane C. isoflurane D. enflurane Ans: b. 2. A young boy has sickle cell trait. Which of the following anaesthesia is contraindicated? A. IV regional anaesthesia B. Brachial plexus block by supraclavicular approach C. Brachia plexus block by infraclavicular approach D. Brachial plexus block by axillary approach Ans: a. 3. Local anaesthesia causing methemoglobinemia â€“ A. Procaine B. Prilocaine C. Etiodicaine D. Ropivacaine Ans: b. ANATOMY 4. Extrinsic membranes of larynx are all except: A. Cricothyroid B. Thyrohyoid C. Hyoepiglottie D. Cricotracheal Ans: A. 5. Paneth cells â€“ true is A. Rich in rough endoplasmic reticulum B. High zine content C. Foamy cytoplasm D. Numerous lysozyme granules Ans: A. 6. True about prostatic urethra are all except: A. Trapezoid in cross section B. Presence of verumontanum C. Openings of prostatic ducts D. Contains urethral crest Ans: A. 7. Cranial nerve not carrying parasympathetic fibres A. Fourth B. Seventh C. Third D. Ninth Ans: A. 8. Middle superior alveolar nerve is a branch of A. Mandibular division of trigeminal nerve B. Palatine division of maxillary nerve C. Anterior nasal division of maxillary nerve D. Inferior alveolar nerve Ans is none 9. A healthy young athlete is sitting at the edge of the table with knee at 90 degree flexion. He fully extends it. What will happen? A. Movement of tibial tuberosity towards centre of the patella B. Movement of tibial tuberosity towards lateral border of patella C. Movement of tibial tuberosity towards medical border of patella D. No change in position Ans: b. 10. Coeliac plexus is located A. Anterolateral & around the aorta B. Posterolateral & around the aorta C. Anteromedical to lumbar sympathetic chain D. Posterolateral to lumbar sympathetic chain Ans: c. 11. Anterior ethmoidal nerve supplies all except: A. Maxillary sinus B. Interior of nasal cavity C. Dural sheath of anterior cranial fossa D. Ethmoidal air cells Ans: d. 12. Appendix epiploicae present in A. Appendix b. Caecum C. Rectum D. Sigmoid colon Ans: a. 13. All of the following muscles retract the scapula except: A. Trapezius B. Rhomboid major C. Rhomboid minor D. Levator scapulae Ans: d. 14. The function of 8th cranial nerve is related to A. smell B. taste C. Touch D. Balance Ans: d. 15. Pain insensitive structure in brain is: A. Falx cerebri B. Dural sheath surrounding vascular sinuses C. Middle meningeal artery D. Choroid plexus Ans: d. 16. Which is not supplied by pelvic splanchnic nerves? A. rectum B. urinary bladder C. appendix D. Uterus Ans: c. BIOCHEMISTRY 17. Eukaryotic plasma membrane is made up of all except: A. Carbohydrates B. Triglycerides C. Lecithin D. Cholesterol Ans: b. 18. Acetyl coA can be directly converted to all except: A. glucose B. fatty acids C. cholesterol D. ketone bodies Ans: a. 19. A 40 yr old woman presents with progressive palmoplantar pigmentation. X-ray spine shows calcification of intervertebral discs. On adding Benedictâ€™s reagent to urine, it gives greenish brown precipitate and blue-black supernatant fluid. What is the diagnosis? A. phenyketonuria B. alkaptonuria C. tyrosinemia type-2 D. argininosuccinic aciduria Ans: b. 20. After overnight fasting, levels of glucose transporters reduced in A. brain cells B. RBCs C. adipocytes D. hepatocytes Ans: c. 21. Splicing activity is a function of: A. mRNA B. snRNA C. tRNA D. rRNA Ans: b. 22. After digestion by restriction endonucleases DNA strands can be joined again by: A. DNA polymerase B. DNA ligase C. DNA topoisomerase D. DNA gyrase Ans: b. 23. True about sickle cells are all, except: A. Single nucleotide change results in change of glutamine to valine B. Sticky patch is generated as a result of replacement of a non polar residue with a polar residue C. HbS confers resistance against malaria in heterozygotes D. RFLP results from a single base change Ans: b. ENT 24. Infection of CNS spreads in inner ear through A. Cochlear aqueduct B. Endolymphatic sac C. Vestibular aqueduct D. Hyrtle fissure Ans: a. 25. Most common site for CSF rhinorrhoea is: A. Ethmoidal sinuses B. Maxillary sinuses C. Frontal sinuses D. Tegmen tympani Ans: a. 26. Endolymph in the inner ear: A. Is a filterate of blood serum B. Is secreted by stria vascularis C. Is secreted by basilar membrane D. Is secreted by hair cells Ans: b. 27. Bellâ€™s palsy patient comes on day 3. treatment given would be: A. Intratympanic steroids B. Oral steroids + vitamin B C. Oral steroids + Acyclovir D. Vitamin B + vasodilators Ans: c. FORENSIC 28. Heat rupture is characterized by A. irregular margin B. Clotted blood C. regular margin D. clotted blood vessels Ans: d. 29. Motorcyclist fracture among the following is A. ring facture B. sutural separation C. comminuted fracture of vault of skull D. Fracture base of skull into anterior & posterior halves Ans: d. 30. A child brought with suspected ingestion, presented with dry mouth, dilated pupil, difficulty in swallowing, delirium, dry & warm skin, the substance is: A. Anti-cholinergic B. Sympathetic C. Cholinergic D. Alpha-blocker Ans: a. 31. Incisional wound on genital is seen commonly in: A. accidents B. Suicides C. Homicides D. Postmortem artifact Ans: c. 32. Destructive power of bullet is determined by: A. weight of bullet B. shape of bullet C. Size of bullet D. velocity of bullet Ans: d. GYNAE & OBSTETRICS 33. Causes of primary amenorrhea are all except â€“ A. Rokitansky syndrome B. Sheehan syndrome C. Kollman syndrome D. Turner syndrome Ans: b. 34. A lady with placenta previa delivered a baby. She had excessive bleeding and shock. After resuscitation most likely complication would be â€“ A. Galactorrhoea B. Diabetes insipidus C. Loss of menstruation D. Cushingâ€™s syndrome Ans: c. 35. The presence of increased levels of which of the following in amniotic fluid is an indicator of open neural tube defect in the fetus? A. Phosphatidylesterase B. Acetyl cholinesterase C. Pseudocholine esterase D. Butyrylcholine esterase Ans: b. 36. A 35 yr old P 3+0 is observed to have CIN grade III on colposcopic biopsy. Best treatment will be â€“ A. Cryosurgery B. Conization C. LEEP D. Hysterectomy Ans: c. 37. A pregnant lady had no complaints but mild cervical lymphadenopathy in first trimester. She was prescribed spiramycin but she was non-complaint. Baby was born with hydrocephalous and intracerebral calcification. Which of the these is likely cause? A. Toxoplasmosis B. CMV C. Cryptococcus D. Rubella Ans: a. 38. Which of the following treatments for menorrhagia is not supported by evidence? A. Tranexamic acid B. Ethamylate C. Combined OCP D. Progesterone Ans: b. 39. A pregnant female at 35 wks of pregnancy is diagnosed with SLE. Drugs that can be used to treat are all except: A. Corticosteroids B. Sulphasalazine C. Methotrexate D. Hydroxychloroquine Ans: c. 40. Vaginal delivery can be allowed in all except â€“ A. Monochorionic, monoamniotic twins B. Mentoanterior C. Extended breech D. Dichorionic twins with first vertex & second breech Ans: a. 41. A lady undergoes total radical hysterectomy for stage Ib Ca cervix. It was found that Ca extends to lower part of body of uterus and upper part of cervix. Next step of management will be â€“ A. Chemotherapy B. Radiotherapy C. Chemoradiation D. Follow-up Ans: d. 42. A 35 yr old woman presents with primary infertility & palpable pelvic mass. Her CA-125 level is 0 U/ml. Diagnosis is â€“ A. Ovarian Ca B. Endometrioma C. Tuberculosis D. Borderline ovarian tumor Ans: b. 43. Ideal contraceptive for lactating mothers is: A. Barrier method B. Combined OCP C. Lactational amenorrhea D. Progesterone only pill Ans: c. 44. Test for ovarian reserve â€“ A. LH B. LH/FSH ratio C. FSH D. Estradiol Ans: c. 45. At what gestational age should a pregnancy with cholestasis of pregnancy be terminated? A. 34 weeks B. 36 weeks C. 38 weeks D. 40 weeks Ans: c. 46. Clomphene citrate â€“ True statement is â€“ A. Enclomiphene is anti-estrogenic B. Increases pregnancy rate 3 times as compared to placebo C. Incidence of twin pregnancy is 5-6% D. It has been shown to increase fertility in oligospermic males in randomized controlled trials Ans: a. 47. Pain of ovarian carcinoma is referred to â€“ A. back to thigh B. gluteal region C. anterior surface of thigh D. medial surface of thigh Ans: d. 48. All are seen in gestational diabetes except â€“ A. Previous macrosomic baby B. Obesity C. Malformations D. Polyhydramnios Ans: c. MEDICINE 49. Radiological features of left ventricular heart failure are all, except: A. kerly B lines B. cardiomegaly C. oligenic lung fields D. increased flow in upper lobe veins Ans: c. 50. Which is the most common childhood CNS tumor to metastasize outside brain? A. ependymoma B. glioblastoma multiforme C. choroids plexus tumor D. medulloblastoma Ans: d. 51. Hypersensitivity vasculitis affects â€“ A. Post-capillary venules B. Arterioles C. Veins D. Medium-zised arteries Ans: a. 52. Hyperextensibility with normal elastic recoil is a feature of â€“ A. Ehlers Danlos syndrome B. Pseudoxanthoma elasticum C. Cutis laxa D. Scleroderma Ans: a. 53. Which of the following about artherosclerosis is true? A. Intake of PUFA associated with decreased risk B. Thoracic aorta involvement is more severe than abdominal aorta involvement C. Extent of lesion in veins is same as that in arteries D. Hypercholesterolemia does not always increase the risk of atherosclerosis per se Ans: a. 54. A girl presented with severe hyperkalemia and peaked T waves on ECG. Fasted way of shifting potassium intracellularly is â€“ A. calcium gluconate IV B. oral resins C. insulin + glucose D. Sodium bicarbonate Ans: c. 55. Features of hypocalcemia are A/E â€“ A. numbness & tingling B. circumoral & paresthesis C. depressed tendon reflexes D. skin irritability & sensitivity Ans: c. 56. A young man back from leisure tri has swollen knee joints & foreign body sensation in eyes. Likely cause is â€“ A. reiterâ€™s syndrome B. Sarcoidosis C. Behcetâ€™s disease D. SLE Ans: a. 57. Cause of vasodilatation in spider nevi â€“ A. estrogen B. testosterone C. Hepatotoxins D. FSH Ans: a. 58. A patient presented with arthritis and purpura. Laboratory examination showed monoclonal and polyclonal cryoglobulins. Histopathology showed deposits of cryoglobins around the vessels. The patient should be tested for which of the following? A. HBV B. HCV C. EBV D. parvovirus Ans: b. 59. Hepatomegaly is the essential feature of all the following except â€“ A. Hepatic porphyria B. Nieman pick disease C. Von gierkeâ€™s disease D. hurler syndrome Ans: a. 60. Rapid infusion of insulin causes â€“ A. hyperkalemia B. hypokalemia C. hypernatremia D. hyponatremia Ans: b. 61. Digitalis toxicity enhanced by A/E â€“ A. renal failure B. Hyperkalemia C. hypercalcemia D. hypomagnesemia Ans: b. 62. True about hemochromatosis â€“ A. Is genetically heterogenous B. Cannot be treated by phlebotomy C. Completely penetrant D. More common in females Ans: a. 63. Strawberry gingivitis seen in â€“ A. Myelocytic infiltration B. Phenytoin toxicity C. Wegner granulomatosis D. Klipel renaunay syndrome Ans: c. 64. A child presents with recurrent episodes of lip and laryngeal edema and abdominal pain associated with stress levels of which of the following are reduced. A. C3 B. C5a C. C1 estease inhibitor D. C9 Ans: c. 65. Best test for initial malabsorption â€“ A. D-xylose test B. NBT-PABA Test C. Fecal fatestimation D. Schilling test Ans: a. 66. All are true about temporal arthritis except â€“ A. Can leads to sudden bilateral blindness B. More common in females C. Worsen on exposure to heat D. Mostly affects elderly Ans: c. 67. A pt presents with acute rheumatic carditis with fever. True statement is â€“ A. Increase troponin T B. Reduced myocardial contractibility C. Signs of inflammation and necrosis D. Valve replacement will ameliorate C.C.F. Ans: d. 68. Cardiovascular complications of HIV infection include all of the following except â€“ A. pericardial effusion B. Cardiac tamponade C. Cardiomyopathy D. Aortic Aneurysm Ans: d. MICROBIOLOGY 69. A male patient presented with granulomatous penile ulcer. On Wright geimsa stain tiny organisms of 2 microns within macrophages see. What is the causative organism? A. LGV B. Calymmatobacterium grabulomatis C. Neisseria D. Staph aureus Ans: b. 70. Diagnostic of Rabies â€“ A. Guarneri bodies B. Negri bodies C. Cowdry a body D. Bollinger bodies Ans: b. 71. Streptococcus all are true except â€“ A. streptodornase cleaves DNA B. streptolysis O is active in reduced state C. Streptokinase is produced from serotype A, C, K D. pyrogenic toxin A is plasmid mediated Ans: d. 72. Superantigens true is â€“ A. they bind to the cleft of the MHC B. Needs to processed before presentation C. they are presented by APCâ€™s to T cells D. directly attached to lateral aspect of TCR beta chain Ans: d. 73. Not used in leptospirosis â€“ A. microscopic agglutination test B. dark field illumination C. macroscopic agglutination test D. Weil felix reaction Ans: d. 74. Lymes disease all are true except â€“ A. Borellia bourgdorferi replicates locally and invades locally B. Infection progresses inspite of good humoral immunity C. Polymorphonuclear lymphocytosis in CSF suggest meningial involvement D. IgA intrathecally confirms meningitis Ans: c. 75. HIV pt with malabsotion, fever, chronic diarrhea, with acid fast positive organism. What is the causative agent? A. giardia B. microsporidia C. Isopora D. E. histolytica Ans: c. 76. Most sensitive test for Treponema â€“ A. VDRL B. RPR C. FTA-ABS D. Kahn Ans: c. 77. Maltess cross seen on polarizing microscopy in â€“ A. Cryptococcus neoformans B. Penicillium marneffi C. Blastomyces D. Candida albicans Ans: a. 78. Irradiation can be used to sterilize A/E â€“ A. Bone graft B. Suture C. Artificial tissue graft D. Bronchoscope Ans: d. 79. Malabsorption caused by A/E â€“ A. Giardia B. Ascaris lumbricoides C. Strongyloides D. Capillaria philipensis Ans: b. 80. Antigen antibody precipitation is maximally seen in which of the following? A. excess of antibody B. excess of antigen C. equivalence of antibody and antigen D. antigen hapten interaction Ans: c. ORTHOPEDICS 81. Posterior glenohumeral instability can be tested by: A. jerk test B. crank test C. fulcrum test D. sulcus test Ans: a. 82. Meralgia paresthetica is due to involvement of â€“ A. medical cutaneous nerve of thigh B. lateral cutaneous nerve of thigh C. sural nerve D. femoral nerve Ans: b. 83. Characteristic radiological feature of fibrous dysplasia â€“ A. Thickened bone matrix B. Cortical erosion C. Ground glass appearance D. Bone enlargement Ans: c. 84. A 68 yr old man came with pain and swelling and swelling of right knee. Ahlback grade 2 osteoarthritis changes were found on investigation. What is the further management? A. arthroscopic washout B. high tibial osteotomy C. total knee replacement D. conservative Ans: d. 85. A 65 yrs old man with H/O back pain since 3 months. ESR is raised. On examination marked stiffness and mild restriction of chest movements is found. On x-ray, syndesmophytes are present in vertebrae. Diagnosis is â€“ A. Ankylosing spondylitis B. Degenerative osteoarthritis of spine C. Ankylosing hypersteosis D. Lumbar canal stenosis Ans: a. 86. Synovial fluid â€“ all are true except â€“ A. secreted by type A cells B. follows non Newtonian fluid kinetics C. Contains hyaluronic acid D. viscosity is variable Ans: a. 87. A lady presents with right knee swelling. Aspiration was done in which CPPD crystals were obtained. Next best investigation is: A. ANA B. RF C. CPK D. TSH Ans: d. 88. Major mineral of the bone is â€“ A. Calcite B. Hydroxyapatite C. Calcium oxide D. Calcium carbonate Ans: b. 89. Which of the following is a pulsatile tumor? A. Osteosarcoma B. Chondrosarcoma C. Ewingâ€™s sarcoma D. Osteoclastoma Ans: d. OPHTHALMOLOGY 90. Disease with autosomal dominant inheritance is â€“ A. bestâ€™s disease B. bassen-kornzwig disease C. gyrate atrophy D. Laurence-Moon-Biedle syndrome Ans: a. 91. A patient presented with unilateral proptosis which compressible and increases on bending forward. No thrill or bruit was present. MRI shows a retroorbital mass with enhancement. The likely diagnosis is â€“ A. AV malformations B. Orbital encephalocoecle C. Orbital varix D. Neurofibromatosis Ans: c. 92. All are common cause of childhood blindness except A. Malnutrition B. Glaucoma C. Ophthalmia neonatorum D. Congenital dacryocystitis Ans: d. 93. Which of the following does not scavenge free radicals in the lens? A. Vit A B. Vit C C. Vit E D. Catalase Ans: a. 94. Mucopolysaccharide hyaluronic acid is present in â€“ A. Vitreous humor B. Cornea C. Blood vessels D. Lens Ans: a. RADIOLOGY 95. A male was brought unconscious to the hospital with external injuries. CT brain showed no midline shift, but basal cisterns were compressed with multiple small hemorrhages. What is the diagnosis? A. cortical contusion B. Cerebral laceration C. Multiple infarcts D. Diffuse axonal injuries Ans: d. 96. A newborn presents with congestive heart failure, on examination has bulging anterior fontanellae with a bruit on auscultation. Transfontanellar USG shows a hypoechoic midline mass with dilated lateral ventricles. Most likely diagnosis is â€“ A. Medulloblastoma B. Encephalocele C. Vein of Galen malformation D. Arachnoid cyst Ans: c. 97. A 48 yr old woman with B/I progressive weakness of both lower limbs, spasticity & mild impairment of respiratory movements. MRI shows an intradural mid-dorsal midline enhancing lesion. What is the diagnosis? A. Intradural lipoma B. Meningioma C. Neuroenteric cyst D. Dermoid cyst Ans: b. 98. Which of the following feature of thyroid nodule on USG is not suggestive of malignancy? A. Hyperechogenecity B. Hypoechogenecity C. Non-homogenous D. Microcalcification Ans: a. 99. Investigation of choice for a lesion of temporal bone â€“ A. CT B. MRI C. USG D. Plain x-ray Ans: a. PHYSIOLOGY 100. Hyperaldosteronism is associated with all except A. Hypernatremia B. Hypokalemia C. Hypertension D. Metabolic acidosis Ans: d. 101. Intrinsic factor of Castle is secreted by A. chief cells B. parietal cells C. mucous cells D. beta cells Ans: b. 102. The main cause of increased blood flow to exercising muscles is A. raised blood pressure B. vasodilatation due to local metabolites C. increased sympathetic discharge to peripheral vessels D. increased heart rate Ans: b. 103. Appetite stimulated by all except A. agouti related peptide B. melanocyte concentrating hormone C. melanocyte stimulating hormone D. neuropeptide Y Ans: c. 104. True about spinocerebellar tract is: A. equilibrium B. Smoothens and coordinates movement C. Learning induced by change in vestibulocular reflex D. planning and programming Ans: b. 105. Capacitance of sperms takes place in: A. Seminiferous tubules B. Epididymis C. Vas deference D. uterus Ans: d. 106. Not done by insulin: A. Glycogen synthesis B. Glycolysis C. Lipogenesis D. Ketogenesis Ans: d. 107. Somatomedin mediates: A. Deposition of chondroitin sulfate B. Lipolysis C. Gluconeogenesis D. Decreased rate of glucose uptake by cells Ans: a. PSM 108. Leprosy involves all except: A. uterus B. Ovary C. Nerve D. Eye Ans: a. 109. True about global warming is: A. CO2 is the major greenhouse gas B. Stratosphere ozone layer is harmful C. CFC increases stratosphere ozone layer D. Kyoto protocol called for 20% reduction in green house effect Ans: a. 110. Incidence can be calculated by A. case-control study B. Prospective study C. Retrospective study D. Cross-sectional study Ans: b. 111. All are true about Aedes except: A. Bites repeatedly B. Eggs cannot survive for more than a week without water C. Transmits dengue D. It takes 7-8 days to develop the parasite and transmit disease Ans: b. 112. All of the following statements about purification of water are true except: A. Presence of clostridial spores indicate recent contamination of water B. Coliforms must not be detectable in any 100 ml sample of drinking water C. Sodium thiosulphate is used to neutralize chlorine D. Coliforms may be detected by multiple tube method & indole production Ans: a. 113. Not seen in fetal pollution A. staphylococcus B. Streptococcus C. E. coli D. Clostridrium perfringens Ans: a. 114. Vitamin A prophylaxis to a child is: A. Health promotion B. Specific Protection C. Primordial prevention D. Secondary prevention Ans: b. 115. Savlon contains A. Cetrimide + Chlorheximide B. Cetrimide + Chlorheximide + butyl alcohol C. Cetrimide + butyl alcohol D. cetrimide + Cetavlon Ans: a. 116. Not true about crude birth rate A. It is a measure of fertility B. It is actually a ratio not a rate C. It is independent of age of population D. Numerator does not include still births Ans: b. 117. Direct standarlization is used to compare the mortality rates between two countries. This is done because of the differences in: A. Causes of death B. Numerators C. Age distributions D. Denominators Ans: c. 118. A test has high false positive rate in a community. True is A. high specificity B. high sensitivity C. high prevalence D. low prevalence Ans: d. 119. Weight of Indian reference man in kg: A. 55 B. 60 C. 50 D. 45 Ans: b. 120. Chlorine demand of water is measured by A. Horrockâ€™s apparatus B. Chlorimeter C. Double pot D. Berkfeld filter Ans: a. 121. Which of the following diseases is not included in â€œVision 2010 right to sightâ€ immediate goals? A. trachoma B. epidemic conjunctivitis C. cataract D. Onchocerciasis Ans: b. 122. Which of the following statements about lepromin test is not true? A. it is negative in most children in first 3 month of life B. it is a diagnostic test C. it is an important aid to classify type of leprosy disease D. BCG vaccination may convert lepra reaction from negative to positive Ans: b. 123. Disease not transmitted by Lice is: A. relapsing fever B. Trench fever C. Q-fever D. epidemic typhus Ans: c. 124. Chikungunya is transmitted by A. aedes B. culex C. mansonoides D. anopheles Ans: a. 125. In a study following interpretation are obtained: Satisfied, very satisfied, dissatisfied. Which type of scale is this? A. nominal B. ordinal C. interval D. ratio Ans: b. 126. Treatment of choice for sputum positive pulmonary tuberculosis detected in 1st trimester of pregnancy: A. defer till second trimester B. start cat. I immediately C. start cat. II immediately D. Start cat. III immediately Ans: b. 127. Safe disposal of mercury is: A. Collect carefully and recycle B. Controlled combustion C. Treatment with chemicals D. Deep burial Ans: a. 128. You have diagnosed a patient clinically as having SLE and ordered 6 tests. Out of which 4 tests have some positive and 2 are negative. To determine the probability of SLE at this point, you need to know: A. Prior probability of SKE; sensitivity and specificity of each test B. Incidence of SLE and predictive value of each test C. Incidence and prevalence of SLE D. Relative risk of SLE in this patient Ans: a. 129. STEPS done for A. surveillance of risk factors of non-communicable disease B. Surveillance of incidence of non-communicable disease C. Surveillance of evaluation of treatment of non-communicable disease D. Surveillance of mortality from non-communicable disease Ans: a. 130. The best graphic representation of frequency distribution data gathered of a continuous variable is: A. Simple bar graph B. multiple bar C. Line diagram D. Histogram Ans: d. 131. Vaccine with maximum efficacy is A. OPV B. Measles C. BCG D. TT Ans: b. 132. True about arboviruses is: A. Yellow fever is endemic in India B. dengue has only one serotype C. KFD was first identified in West Bengal D. Chikungunya is transmitted by Aedes aegypti Ans: d. PHARMACOLOGY 133. Which is not used in treatment of heroin dependence? A. disulfiram B. buprenorphine C. clonidine D. lofexidine Ans: a. 134. All of the following drug is CYPA inhibitor except: A. erythromycin B. itraconazole C. ritonavir D. saquinavir Ans: d. 135. Most common dose limiting toxicity of chemotherapeutic agent? A. Myelosuppression B. G.I. toxicity C. Neurotoxicity D. Alopecia Ans: a. 136. Oligospermia caused by â€“ A. Methotrexate B. Hydroxychloroquine C. Leflunomide D. D-peniollamine Ans: a. 137. Drug of choice for Zollinger-Ellison syndrome â€“ A. antihistaminics B. Proton lump inhibitors C. Dopamine agonists D. Antacids Ans: b. 138. Which one of the following drugs cause hypomagnesemia by increased excretion? A. Frusemide therapy B. Cisplatin C. Digitalis D. Aminoglycosides Ans: a. 139. Pharmacovigilance is done for monitoring â€“ A. drug price B. unethical practices C. drug safety D. pharmacology students Ans: c. 140. Which of the following drugs is both antiresoptive and bone formative? A. strontium ranelate B. calcitonin C. ibadronate D. teriperatide Ans: a. 141. Thalidomide is used in all except â€“ A. HIV induced peripheral neuropathy B. HIV induced mouth ulcer C. Bechetâ€™s syndrome D. Erythema nodosum leprosum Ans: a. 142. Which is not an alkylating agent? A. 5-FU B. Chlorambucil C. Melphalan D. Cyclophosphamide Ans: a. 143. Drug not used in pulmonary hypertension â€“ A. Calcium channel blocker B. Endothelin receptor antagonist C. Alpha blocker D. Prostacyclin Ans: c. 144. Opioid agonist are A/E â€“ A. Morphine B. Codeine C. Ketamine D. Methadone Ans: c. PATHOLOGY 145. CD4 â€“ is not important for which of the following â€“ A. antibody production B. cytotoxicity of T cells C. memory B cells D. opsonisation Ans: d. 146. Characteristic feature of acute inflammation â€“ A. vasoconstriction B. vascular stasis C. vasodilatation and increased vascular permeability D. margination of leucocytes Ans: c. 147. Main feature of chemotaxis is â€“ A. increased random movement of neutrophils B. increased adhesiveness to intima C. increased phagocytosis D. unidirectional locomotion of neutrophils Ans: d. 148. Central organ in apoptosis â€“ A. mitochondria B. nucleus C. ER D. golgi body Ans: a. 149. Coagulative necrosis is seen in â€“ A. T.B. B. Sarcoidosis C. Cryptococcal infection D. gangrene Ans: a. 150. Best investigation for diagnosing amyloidosis â€“ A. Rectal biopsy B. Colonoscopy C. CT scan D. Upper GI endoscopy Ans: a. 151. Caspases are associated with â€“ A. Organogenesis B. Hydropic degeneration C. Collagen hyalinization D. ---------- Ans: a. 152. Two siblings with osteogenesis imperfect, but their parents are normal. Mechanism of inheritance is â€“ A. Anticipation B. Genomic imprinting C. Germ line mosaicism D. New mutation Ans: c. 153. What is the mechanism of acute rheumatic fever â€“ A. cross reactivity with endogenous antigen B. innocent by slender effect C. due to toxin secretion by streptococci D. release of pyrogenic cytokines Ans: a. 154. Which of the following is associated with aging â€“ A. reduced cross linkages in collagen B. increased free radical injury C. decreased somatic mutations in DNA d. increased superoxide dismutase levels Ans: b. 155. CD marker specific for myeloid series â€“ A. CD34 B. CD 45 C. CD 99 D. CD117 Ans: c. 156. Berry aneurysm â€“ Defect lies in â€“ A. degeneration of internal elastic lamina B. degeneration of media / muscle cell layer C. Deposition of mucoid material in media D. low grade inflammation of vessel wall Ans: b. PEDIATRICS 157. True about cowâ€™s milk are all except â€“ A. Cowâ€™s milk contains 80% whey protein not casein B. Cowâ€™s milk has less carbohydrate than mothers milk C. Has more k+ and Na+ than infant formula feeds D. Has more protein than breast milk Ans: a. 158. Eisenmenger syndrome â€“ True are A/E â€“ A. Pulmonary veins are not distended B. RV & LV walls come back to normal size C. Dilatation of central pulmonary artery D. Peripheral pruning of pulmonary arteries Ans: b. 159. All are signs of impending Eisenmenger except â€“ A. Increased flow murmur across tricuspid & pulmonary valve B. Single S2 C. Loud P2 D. Graham steel murmur Ans: a. 160. Most sensitive indicator of intravascular volume depletion in infant â€“ A. Stroke volume B. Heart rate C. Cardiac output D. Blood pressure Ans: b. 161. An alert 6 months old child is brought with vomiting & diarrhea. RR-45/min, HR-130/min, SBP-85 mm of Hg. Capillary refilling time is 4 secs. Diagnosis is â€“ A. early compensated hypovolemic shock B. early decompensated hypovolemic shock C. late compensated hypovolemic shock D. late decompensated hock due to SVT Ans: a. 162. Which of the following is a component of pentalogy of Fallot â€“ A. ASD B. PDA C. Coarctation of aorta D. LVH Ans: a. 163. Congenital toxoplasmosis â€“ False is â€“ A. Diagnosed by detection of IgM in cord blood B. IgA is more sensitive than IgM for children C. Dye test is gold standard for IgG D. Avidity testing must be done to differentiate between IgA and IgM Ans: d. 164. 6 weeks old female baby found unconscious suddenly in the crib. She was previously healthy. Normal blood pressure, hyperpigmentation of genitals, blood glucose 30 mg/dl. Diagnosis is â€“ A. CAH due to 21-alpha hydroxylase deficiency B. Familial glucocorticoid deficiency C. Cushing syndrome D. Insulinoma Ans: b. 165. Best indicator of growth monitoring in children â€“ A. Weight B. Mid-arm circumstance C. Rate of increase in height & weight D. Head circumstance Ans: c. 166. A child presents with failure to thrive with frequent vomiting, diarrhea, hepatic splenomegaly & abdominal distention. CT shows adrenal calcification. Which of the following is the diagnosis? A. Adrenal hemorrhage B. Wolmanâ€™s disease C. Pheochromocytoma D. Addisonâ€™s disease Ans: b. SURGERY 167. Commonest organ injured in blast injury is â€“ A. Lung B. Liver C. Spleen D. Pancreas Ans: a. 168. In blunt trauma abdomen what should be the approach for doing laparotomy â€“ A. Depends on organ injured B. Always midline incision C. Always transverse D. Depends upon type of injury Ans: b. 169. A well differentiated follicular carcinoma of thyroid can be best differentiated from a follicular adenoma by: - A. Hurthle cell change B. Lining of tall columnar and cuboidal cells C. Vascular invasion D. Nuclear features Ans: c. 170. True about brachial anomaly â€“ A. Cysts are more common than sinuses B. For sinuses surgery is not always indicated C. Cysts present with dysphagia and hoarseness of voice D. Most commonly due to 2nd brachial remnant Ans: d. 171. Best prognostic factor for head injury is: A. Glassgow coma scale B. Age C. Mode of injury D. CT findings Ans: a. 172. Most common site of Morgagni hernia: A. Right anterior B. right posterior C. right anterior D. left posterior Ans: a. 173. About congenital torticollis all are true except: A. Always associated with breech extraction B. Spontaneous resolution in most cases C. 2/3rd cases have palpable neck mass at birth D. Uncorrected cases develop plagiocephaly Ans: a. 174. Psammoma bodies seen in A/E â€“ A. Follicular CA of thyroid B. Papillary CA of thyroid C. Serous cystadenocarcinoma of ovary D. Meningioma Ans: a. 175. Barrettâ€™s esophagus shows: A. Intestinal dysplasia B. Intestinal metaplasia C. Squamous cell metaplasia D. Columnar cell metaplasia Ans: b. 176. 50 year old male with positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer is: A. DRE B. PSA C. DRE + PSA D. Endorectal Coil MRI with T1W and T2W images Ans: c. 177. Orchidopexy for cryptorchidism is done at the age of: A. 1 to 2 years B. 5 to 6 years C. Puberty D. Neonatal period Ans: a. 178. Which of the following colonic polyps has no risk for malignancy? A. Juvenile polyps B. Hamartomatous polyps associated with Peutz-Jegherâ€™s syndrome C. Juvenile polyposis syndrome D. Famillial adenomatous polyposis syndrome Ans: a. 179. Peutz Jeghers polyps present most commonly in â€“ A. rectum B. colon C. esophagus D. jejunum Ans: d. 180. Congenital hypertrophic pyloric stenosis associated with â€“ A. hypokalemic acidosis B. hypokalemic alkalosis C. hyperkalemic acidosis D. hyperkalemic alkalosis Ans: b. 181. Renal calculi associated with Proteus infection â€“ A. Uric acid B. Triple phosphate C. Calcium oxalate D. Xanthine Ans: b. 182. Sister Mary Joseph nodule is most commonly seen with â€“ A. Ovarian cancer B. Stomach cancer C. Colon cancer D. Pancreatic cancer Ans: b. 183. In order to expose the celiac axis, left renal artery, superior mesenteric artery and abdominal aorta in a case of trauma, which of the following is performed: A. Left medial visceral rotation B. right medial visceral rotation C. cranial visceral rotation D. caudal visceral rotation Ans: a. 184. Which of the following is not true about FAP? A. AR inheritance B. Screening done by sigmoidoscopy C. Polyps develop in late adulthood D. Epidermal cysts & osteomas may occur Ans: a. 185. Wilmâ€™s tumor associated with A/E â€“ A. Hemihypertrophy B. Aniridia C. Hypertension D. Bilateral polycystic kidney disease Ans: d. 186. All of the following genes may be involved in development of carcinoma of colon except â€“ A. APC B. Beta-Cetanin C. K-ras d. Mismatch repair genes Ans: b. 187. Early post-operative complication of ileostomy in the post-operative period â€“ A. Obstruction B. Necrosis C. Diarrhea D. Prolapse Ans: b. 188. Smoking may be associated with all of the following cancers, except â€“ A. Ca larynx B. Ca Nasopharynx C. Ca bladder D. Ca esophagus Ans is None. 189. A 60 yr old chronic smoker presents with painless gross hematuria of 1 days duration. Investigation of choice to know the cause of hematuria â€“ A. USG B. X-ray KUB C. Urine routine D. Urine microscopy for malignant cytology cells Ans: d. 190. Hashimotoâ€™s thyroiditis â€“ true are A/E â€“ A. Follicular destruction B. Increase in lymphocytes C. Oncocytic metaplasia D. Orphan Annie eye nuclei Ans: d. 191. A man with blunt abdominal trauma with H/O pelvic fracture has presented to ER. He has passed only few drops of blood per meatus and no urine in the past 8 hrs. His bladder is palpable per abdomen. Which of the following is correct? A. Anuria due to hemorrhagic shock B. Urethral injury C. Ureteral rupture leading to extravasation of urine in retroperitoneum D. Bladder rupture Ans: b. PSYCHIATRY 192. A 3 year old girl has normal development milestones except delay in speech. She has difficulty in concentration communication and relating to others and does not make friends but plays with herself. Likely diagnosis is â€“ A. ADHD B. Autism C. Specific learning disorder D. Mental retardation Ans: b. 193. Drug of choice in Obsessive compulsive disorder is: A. Imipramine B. Fluoxetine C. Alprazolam D. Chlorpromazine Ans: b. 194. Naltrexone is used in opioid dependence to â€“ A. Prevent respiratory depression B. Treat withdrawal symptoms C. Prevent relapse D. Treatment of opioid overdose Ans: c. 195. Most common substance abuse in India is â€“ A. Tobacco B. Cannabis C. Alcohol D. Opium Ans: a. 196. A young lady presents with repeated episodes of excessive eating followed by purging by use of laxatives. What is the diagnosis? A. Bulimia nervosa B. Binge eating C. Schizophrenia D. Anorexia nervosa Ans: a. SKIN 197. Which of the following is not a primary skin disease? A. Reiterâ€™s syndrome B. Bowenâ€™s disease C. Psoriasis D. Lichen planus Ans: a. 198. 25 yr old male having fever & malaise since 2 weeks, arthritis of ankle joint and tender erythematous nodules over the shin. Diagnosis is â€“ A. Erythema nodosum B. Hensenâ€™s disease C. Weber-Christian disease D. Urticardial vasculitis Ans: a. 199. Chang staging is used for A. retinoblastoma B. medulloblastoma C. ewingâ€™s sarcoma D. rhabdomysarcoma Ans: b. 200. Which component of the eye has highest refractive index? A. Anterior surface of the lens B. Posterior surface of the lens C. Centre of the lens D. Cornea Ans: c.