cardiac and renal transplantation

Discussion in 'MRCS Forum' started by Lona., Jan 26, 2008.

  1. Lona.

    Lona. Guest

    Q. A patient requires both cardiac and renal transplantation. Preparation for the procedures is begun. How do cardiac allografts differ from renal allografts?

    a- Cardiac allografts are matched by HLA tissue typing and renal allografts are not
    b- Cardiac allografts can tolerate a longer period of cold ischemia than renal allografts
    c- One-year graft survival for cardiac allografts is substantially lower than that for renal allografts
    d- Cardiac allografts are matched only by size and ABO blood type
    e- Cyclosporine is a critical component of the immunosuppressive regimen for cardiac allografts but not renal allografts
  2. Lona.

    Lona. Guest

    Answer: d. (Greenfield, 2/e, pp 599-606) Cardiac allograft has become an accepted treatment for end-stage heart disease. One-year cardiac allograft survival approaches 90% and is equivalent to 1-year renal allograft survival. Cardiac allografts have a cold ischemia preservation time of 4 to 5 h, and therefore tissue typing is not practical. Cardiac donors are matched to recipients only by size and ABO blood type. Tissue typing remains to important component of cadaveric kidney allograft matching. The mainstay of immunosuppression for both cardiac and renal allografts continues to include cyclosporine, azathioprine (Imuran), and steroids.

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