CHROMOTHRYPSIS

Discussion in 'DNB CET board - DipNB' started by samuel, Oct 30, 2014.

  1. samuel

    samuel New Member

    CHROMOTHRYPSIS---(Means chromosome shattering; a/k/a dramatic chromosome catastrophe)
    1)seen in OSTEOSARCOMAS(other bone cancers too) and GLIOMAS.
    2) dozens to hundreds of chromosomal breaks occurs in single or several chromosomes,then they are repaired haphazardly
    3)this will activate Oncogenes and inactivate Tumor suppressor gene.
    4)its mechanism of carcinogenesis.

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