Harrison hematology

Discussion in 'AIIMS Nov 2013' started by samuel, Jan 6, 2014.

  1. samuel

    samuel New Member

    @ Shift cells : prematurely released reticulocyte in anemia

    @ Palmar creases lighter than the surrounding skin : Hb level < 8g/dl

    @ EPO producing neoplasm : hepatoma , uterine leiomyoma , RCC

    @ most abundant receptor on platelet surface : Gp2b/3a

    @ serine proteas factor ; factor 7a

    @ cross linking of adjacent D domain of fibrinogen done by : factor 13 a

    @ activated protein c act as anticoagulant by inactivating factor 5 n 8

    @ Plasmin is formed by cleaving of Arg560-Val561 bond of plasminogen

    @ platelet surface receptor Gp6/ FcyR2a bind collagen

    @ TAR syndrome : congenital amegakaryocytic hypoplasia wd absent radii

    @ " white clot syndrome " : heparin induced thrombosis

    @ most severe vWD : type 3

    @ best candidate for desmopressin treatment in vWD ds : type 1 vWD

    @ HEYDE syndrome : aortic stenosis + GI bleeding

    @ TTP : deficiency in ADAMTS13 metalloproteinase

    @ presence of Hyalin thrombi in arterioles , capillaries , venules wd out any inflam cells : diagnostic of TTP

    @ Winterbottom sign : post cervical triangle LNpathy seen T gambience

    @ Romana sign : classic finding of acute chaga ds

    @ percussion for splenic dullness by : Nixon , castell n Barkun method

    @ " Abscopal effect " : regression of systemic ds after splenectomy

    @ Pelger Huet anomaly : bilobed granulocyte wd " pince nez " confuigeration in nucleus

    @ JOB syndrome : hyperIgE recurrent infection syndrome Chr by broad nose kyphoscoliosis , osteoporosis n eczema

    @ principal iron regulatory hormone : Hepcidin it control both uptake n release

    @ Hephestin : oxidizes ferric form for transferrin binding

    @ Lucarelli classification : to access risk factor n prognosis in thalessimia

    @ Hepatocorrin : cobalamine binding protein

    @ Cubilin : mediates absorption of cobalamin - IF complex

    @ Imerslund grasback synd : mutation in Cubilin receptor

    @ mc mutation in AD her spherocytosis : mutation in ANK 1 gene on Chr 8 wch codes for Ankyrin

    @ " pink test " : modified osmotic fragility test

    @ diagnostic of PNH : CD 59 - n CD 55 -

    @ most imp protective RBC protective protein : CD 59

    @ at dose of about 1000 mg / day aspirin also inhibit COX 2

    @ drug that inhibit platelet aggregation n activation : useful in arterial ds
    Drug that inhibit thrombin n fibrin : useful in venous ds

    @ final common pathway for platelet activation : expression of Gp2b/ 3a on platelet surface

    @ main metabolite of clopidogrel : SR 26334

    @ Ticlopedine can produce TTP

    @ heparin binding domain in Thrombin : exosite 2

    @ exosite 1 : for fibrin

    @ 1 mg protamine sulphate neutralizes 100 unit of heparin

    @ Argatroban is predominantly cleared by liver

    @ all vit k dependent clotting factor possess Glutamic acid residue at N terminus

    @ warfarin inhibits vit k epoxide redutase ( VKOR )

    @ in most pt target INR for warfarin treatment is 2 to 3 but in pt wd prosthetic valve it is 2.5. - 3.5

    @ warfarin induced skin necrosis : in Pts of acq protein C or S def n seen in first week of therapy

    @ Osteocalcin : vit k dependent bone matrix protein . Warfarin embryopathy is due to effect on this

    @ bolus fibrinolytic : tenecteplase

    @ Heparin induced thrombocytopenia : IgG formation against heparin PF4 complex n platelet Fc receptor

    @ HIT : most pt develop it after 5 to 10 days of heparin therapy

    @ Evan syndrome : AIHA + ITP

    @ In ITP : dose of IVIg - 2gm/ kg

    @ TTP is also called Moschowitz ds

    @ mc inherited bleeding disorder : vWD ds

    @ Desmopressin acts thru type 2 vasopressin receptor

    @ DDAVP is not recommended in type 2 b vWD as it inc thrombocytopenia

    @ gene that determine A n B bld grp : on Chr 9p

    @ individual wd Bombay phenotype produce ABs to H substance n also A n B Ag

    @ Ag wch act as cellular receptor for plasmodium vivax : Duffy Ag

    @ Macleod synd : def of kell grp blood Ag

    @ each unit of cryoprecipitate contain 80 unit of factor 8

    @ Transfusion related acute lung injury ( TRALI ) occur within 4 hr of bld transfusion

    @ Pappenheimer bodies : hemosiderin containing granule

    @ bacteria mc in causing RBC contamination in Bld transfusion ; yersinia enterocolitica

    @ mc heavy chain ds : Seligmann ds wch is alpha heavy chain ds

    @ Franklin ds : gamma heavy chain ds

    @ skin changes in POEM synd : hyper pigmentation , hypertrichosis ,digital clubbing

Share This Page