Important Questions from mypgmee for AIPGME and DNB

Discussion in 'DNB CET board - DipNB' started by samuel, Nov 7, 2014.

  1. samuel

    samuel New Member

    1. Antiretroviral drug that may be used by sub cutaneous route ?

    a. Ritonavir
    b. Efavirenz
    c. Tenofavir
    d. Enfuritide

    Azodicarbonamide a novel drug for HIV is

    A Zinc finger inhibitor
    B Reverse transcriptase
    C Maturation inhibitor
    D Fusion Inhibitor

    Q: Detanonoate is

    A)Direct bradycardia agent
    B) Rho Kinase inhibitor
    C) Protein Kinase G Facilitator
    d) Nitric oxide donor

    Enfuvirtide works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected. A biomimetic peptide, enfuvirtide was designed to mimic components of the HIV-1 fusion machinery and displace them, preventing normal fusion. Drugs that disrupt fusion of virus and target cell are termed entry inhibitors or fusion inhibitors.

    Indications
    Enfuvirtide is indicated for the treatment of HIV-1 infection, in combination therapy with other antiretrovirals, in patients where all other treatments have failed.

    Dosage forms
    By virtue of its peptide nature, enfuvirtide is marketed in injectable form. The lyophilised enfuvirtide powder must be reconstituted by the patient and administered twice daily by subcutaneous injection. Due to the chronic nature of this kind of therapy, this dosage form may be a major problem for the patient's adherence to this drug regimen.

    Racecadotril------------ also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.Unlike other opioid medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.

    A one-year-old male child presented with right side facial hemangioma since birth along with recent onset focal seizure. CT scan of head is suggestive of unilateral calcifications with cerebral atrophy. What is diagnosis of child?

    a. Transabdominal ultrasound
    b. MRCP
    c. Endoscopic ultrasound
    d. CT

    Answer is B
    The probable diagnosis is Zellweger syndrome, a type of category A peroxisomal biogenesis disorder. Inherited as an autosomal recessive disease (1:100,000 births), it is also called cerebrohepatorenal syndrome. Peroxisomes are virtually absent, as are normal peroxisomal functions, which include the oxidation of very long chain fatty acids.

    Which of the following is the best method to detect choledocholithiasis?
    a. Transabdominal ultrasound
    b. MRCP
    c. Endoscopic ultrasound
    d. CT

    A 2-month-old patient presented with failure to thrive, seizures and nystagmus. Physical examination revealed high foreheads, hypoplastic supraorbital ridges, widely open fontanelles, glaucoma, corneal clouding and hypotonia. Biochemical abnormality included inability to oxidize and accumulation of very long chain fatty acids. The probable diagnosis is:

    a. Gaucher disease
    b. Zellweger syndrome
    c. Classic Refsum disease
    d. Farber lipogranulomatosis

    The probable diagnosis is Zellweger syndrome, a type of category A peroxisomal biogenesis disorder. Inherited as an autosomal recessive disease (1:100,000 births), it is also called cerebrohepatorenal syndrome. Peroxisomes are virtually absent, as are normal peroxisomal functions, which include the oxidation of very long chain fatty acids.

    The characteristic PAS-positive basophilic deposits, seen on electron microscopy, in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are comprised of:
    a. Beta amyloid protein
    b. NOTCH3 protein
    c. Prion protein PRPSc
    d. Tau proteins

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