Malaria recrudescence is

Discussion in 'AIIMS Nov 2013' started by samuel, Dec 17, 2014.

  1. samuel

    samuel New Member

    Malaria recrudescence is-
    a) Resistant to treatment
    b) Relapse of infection
    c) Relapse in vivax and ovale
    d) Re-appearance of asexual stage parasitaemia after treatment.

    Answer: Re-appearance of asexual stage parasitaemia after treatment

    Explanation:
    In infections involving P. vivax and P. ovale
    there may be persistent hypnozoites in the
    liver. They are responsible for relapses of those
    species for periods of up to 8 or 9 years.
    The term for recurrence of infection with other
    species, P. falciparum, P. malariae and P.
    knowlesi, which lack hypnozoites, is
    “recrudescence”, meaning that the infection
    has recurred from persistent blood stages of
    the malaria parasite.
    There are several studies to prove that
    recurrent P. falciparum infection is caused by
    recrudescence of chloroquine resistant
    parasites.
    “Recrudescence” can also occur with P. vivax
    and P. ovale infections when such parasites
    have also persisted in the blood.
    Recrudescence can be due to (1) incomplete or
    inadequate treatment as a result of drug
    resistance or improper choice of medication,
    (2) an antigenic variation, and (3) multiple
    infections by different strains.

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