MASSIVE BLOOD TRANSFUSION

Discussion in 'DNB CET board - DipNB' started by samuel, Oct 30, 2014.

  1. samuel

    samuel New Member

    MASSIVE BLOOD TRANSFUSION
    defined as
    1) adults
    a) replacement of >1 blood volume in 24 hours ,or
    b) >50% of blood volume in 4 hours (adult blood volume is approximately 70 mL/kg).
    2) children,
    • transfusion of >40 mL/kg (blood volume in children over 1 month old is approximately 80 mL/kg).

    Initially TRANSIENT HYPERGLYCEMIA due to glucose in preservatives;
    this leads to insulin release and may cause HYPOGLYCEMIA

    Overall most commonly--- HYPOGLYCEMIA > HYPERGLYCEMIA.

    Most Common cause of death after massive blood transfusion is--- DIC
    (massive RBC transfusion without concomitant repletion of clotting factors may lead to a dilutional coagulopathy.)

    2)TRALI (Transfusion-Related Acute Lung Injury) is the most common cause of major morbidity and death after transfusion. It presents as an acute respiratory distress syndrome (ARDS) either during or within 6 h of transfusion.Most commonly a/w FFP transfusion.

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