Not example of uni-parental disomy a) Angelman syndrome b) Prader-Willi syndrome c) Bloom syndrome d) Silver Russell syndrome Answer: Bloom syndrome Explanation: Bloom syndrome (congenital telangiectatic erythema) is a rare autosomal recessive disorder characterized by telangiectases and photosensitivity, growth deficiency of prenatal onset, variable degrees of immunodeficiency, and increased susceptibility to neoplasms of many sites and types. Uni-parental disomy (UPD) occurs when a person receives two copies of a chromosome or of part of a chromosome, from one parent and no copies from the other parent. The most well-known conditions: Prader-Willi syndrome (UPD 15) Angelman syndrome (UPD 15) Beckwith-Wiedemann syndrome Russell-Silver syndrome (UPD 7) Transient neonatal diabetes (UPD 6) UPD of chromosome 14
