One of the following is a disease caused by Osteoclast dysfunction:

Discussion in 'Question Zone' started by Neha Gupta, May 7, 2013.

  1. Neha Gupta

    Neha Gupta Active Member

    One of the following is a disease caused by Osteoclast dysfunction:

    a. osteoporosis

    b. rickets

    c. renal osteodystrophy

    d. osteogenesis imperfecta
  2. Neha Gupta

    Neha Gupta Active Member

    osteoclast dysfunction:
    - osteopetrosis;
    - paget's disease;
    - gorham-stout syndrome:
    - condition in which there is progressive bone resorption;
    - this condition may be due to an increased number of osteoclasts and may respond to calcitonin or bisphosphonates;
  3. Neha Gupta

    Neha Gupta Active Member

    Osteocalcin
    - vit K dependent protein which regulates the rate of bone synthesis;
    - osteoclacin is the only protein made by osteoclasts exclusively;
    - levels of osteocalcin and other gamma carboxylated glutamic acid containing proteins have been shown to be elevated in serum & urine of
    pts w/ Pagets disease,
    primary hyperparathyroidism, renal osteodystrophy, and high turn over osteoporosis

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