PYROPTOSIS

Discussion in 'DNB CET board - DipNB' started by samuel, Oct 30, 2014.

  1. samuel

    samuel New Member

    form of programmed cell death associated with antimicrobial responses during inflammation.
    initiation of pyroptosis is caused by the recognition of flagellin components of Salmonella and Shigella species (and similar pathogen-associated molecular patterns (PAMPs) in other microbial pathogens) by NOD-like receptors (NLRs).
    (NOTE------NOD-like receptors (NLRs).
    These receptors function like plasma membrane Toll-like receptors (TLRs), but recognise antigens located within the cell rather than outside of it.)
    In contrast to apoptosis, pyroptosis requires the function of the enzyme caspase-1 and Caspase -11.
    caspase-1 is activated during pyroptosis by a large supramolecular complex termed the pyroptosome (also known as an inflammasome containing IL-1 cytokine)
    Pyroptosis differs from Apoptosis by following features (that’s why they are considered as NECROSIS ---- “Caspase dependent programmed cell death” )
    a) Shows cell swelling
    b) Cell membrane damage
    c) Presence of inflammation

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