RB GOVERNOR OF THE CELL CYCLE

Discussion in 'NEET 2013 All india Exam' started by samuel, Nov 3, 2014.

  1. samuel

    samuel New Member

    RB GOVERNOR OF THE CELL CYCLE )
    • When hypophosphorylated, RB exerts antiproliferative effects by binding and inhibiting E2F transcription factors
    • regulate genes required for cells to pass through the G1-S phase cell cycle checkpoint.
    • Normal growth factor signaling leads to RB hyperphosphorylation and inactivation, thus promoting cell cycle progression.
    • The antiproliferative effect of RB is abrogated in cancers through a variety of mechanisms, including:
    1) Loss-of-function mutations affecting RB
    2) Gene amplifications of CDK4 and cyclin D genes
    3) Loss of cyclin-dependent kinase inhibitors (p16/INK4a)
    4) Viral oncoproteins that bind and inhibit RB (E7 protein of HPV)

Share This Page