Some oncogenes are mutants of normal cell-surface receptors that have tyrosine protein kinase motifs

Discussion in 'USMLE STEP 1' started by samuel, Dec 8, 2014.

  1. samuel

    samuel New Member

    Some oncogenes are mutants of normal cell-surface receptors that have tyrosine protein kinase motifs in their cytoplasmic domains. The type of mutation of such a receptor that is most likely to result in cell transformation is a mutant protein with which of the following characteristics?

    A) Constitutive activation of cellular transcription
    B) Deletion of the cytoplasmic domain
    C) Failure to become phosphorylated upon receiving the signal
    D) Failure to receive the signal that normally activates cellular transcription
    E) Recognition of a different signal than usual

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