The use of activated charcoal would be least effective

Discussion in 'MRCS Forum' started by Lona., Nov 23, 2007.

  1. Lona.

    Lona. Guest

    The use of activated charcoal would be least effective in the emergency treatment of ingestion of which of the following?
    a- Phenobarbital
    b- Theophylline
    c- Ferrous sulfate
    d- Digitoxin
    e- Tricyclic antidepressants
  2. Lona.

    Lona. Guest

    Answer: -The answer is C. (Rudolph, 20/e, pp 815-816). The absorption of toxins from the gastrointestinal tract is diminished by the use of activated charcoal administered during the first f ew hours after the ingestion in the minimum dose of 1 g per kilogram of body weight or 5 to 10 times the quantity of the ingested material. Activated charcoal exerts its effect by adsorbing particles of toxin on its surface. Compounds not adsorbed include alcohols, acids, ferrous sulfate, strong bases, cyanide, lithium, and potassium. For drugs with an enterohepatic circulation (e.g. phenobarbital and tricyclic antidepressants) or for those with multiple-dose activated charcoal may be effective in decreasing the half-life and increasing the total body clearance of the toxic substance.

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