toxicity of doxorubicin

Discussion in 'MRCS Forum' started by Lona., Jan 30, 2008.

  1. Lona.

    Lona. Guest

    Q. A patient with a solid malignancy is discussing chemotherapy with his oncologist. He is interested in the risks of the treatment. What is the primary toxicity of doxorubicin (Adriamycin)?
    a- Cardiomyopathy
    b- Pulmonary fibrosis
    c- Peripheral neuropathy
    d- Uric acid nephropathy
    e- Hepatic dysfunction
  2. Lona.

    Lona. Guest

    Answer: a. (Greenfield, 2/e, p 502) Doxorubicin, an antibiotic derived from Streptomyces species, has activity against sarcomas and carcinomas of the breast, liver, bladder, prostate, head and neck, esophagus, and lung. Its major side effect is production of a dilated cardiomyopathy. Patients receiving this agent should have echocardiography before and after treatment in order to monitor potential cardiac toxicity.

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