transmission of viral illness through homologous blood

Discussion in 'MRCS Forum' started by Lona., Nov 28, 2007.

  1. Lona.

    Lona. Guest

    Which statement regarding transmission of viral illness through homologous blood transfusion is true?
    a- The most common viral agent transmitted via blood transfusion in the United States is human immunodeficiency virus (HIV)
    b- Blood is routinely tested for cytomegalovirus (CMV) because CMV infection is often fatal
    c- The most frequent infectious complication of blood transfusion continues to be viral meningitis
    d- Up to 10% of those who develop post-transfusion hepatitis will develop cirrhosis or Hepatoma or both
    e- The etiologic agent in post-transfusion hepatitis remains undiscovered
  2. Lona.

    Lona. Guest

    Answer: D. (Goodnough, Am J Surg 159:602-609, 1990) Cytomegalovirus (CMV) is harbored in blood leukocytes. CMV infection is endemic in the United States, and its prevalence increases steadily with age. While acute CMV infection may cause transient fever, jaundice and hepatosplenomegaly in cases of large blood donor exposures, post-transfusion CMV infection (seroconversion) is not a significant clinical problem in immunocompetent recipients and therefore blood is not routinely tested for the presence of CMV. Post-transfusion non-A, non-B hepatitis, however, not only represents the most frequent infectious complication of transfusion but also is associated with an incidence of chronic active hepatitis up to 16% and an 8 to 10% incidence of cirrhosis or Hepatoma or both. The etiologic agent in over 90% of cases of post-transfusion hepatitis has been identified as hepatitis C.

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