Discussion in 'MRCS Forum' started by Javed., Jan 31, 2008.

  1. Javed.

    Javed. Guest

    Q. Because of the shortage of donor organs, some researchers have experimented with xenotranplantation. Animal organs may substitute for diseased human organs. What is the major barrier to successful transplantation across animal species (xenotransplantation)?

    a- Acute rejection
    b- Chronic rejection
    c- Hyperacute rejection
    d- Infection
    e- ABO incompatibility
  2. Javed.

    Javed. Guest

    Answer: c. (Greenfield, 2/e, p 555) The major barrier to successful xenotranplantation has been hyperacute rejection, which refers to the binding of preformed human antibodies to donor endothelial cells. This results in the activation of complement, cell lysis and eventually vascular thrombosis.

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